An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

doi:10.1172/JCI117778

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Article

An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

The Journal of clinical investigation - 1 Mar 1995

Baier L J, Sacchettini J C, Knowler W C, Eads J, Paolisso G, Tataranni P A, Mochizuki H, Bennett P H, Bogardus C, Prochazka M

Abstract excerpt

The intestinal fatty acid binding protein locus (FABP2) was investigated as a possible genetic factor in determining insulin action in the Pima Indian population. A polymorphism at codon 54 of FABP2 was identified that results in an alanine-encoding allele (frequency 0.71) and a threonine-encoding allele (frequency 0.29). Pimas who were homozygous or heterozygous for the threonine-encoding allele were found to...

Topics

Adult
Alanine
Alleles
Arizona
Base Sequence
Calorimetry
Carrier Proteins
Chromosomes, Human, Pair 4
Diabetes Mellitus, Type 2
Fatty Acid-Binding Protein 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fatty Acid-Binding Proteins

Fatty Acids

Female

Gene Frequency

Glucose

Glucose Clamp Technique

Humans

Indians, North American

Source

Open in PubMed Open full text

Identifiers

PMID: 7883976
DOI: 10.1172/JCI117778
PMCID: PMC441467

Genes

FABP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7883976-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.PMID 7883976Read ↗

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