The A54T polymorphism of fatty acid-binding protein 2 may entail a reduction in fat-stimulated secretion of GIP that potentiates the adverse impact of fatty diets on insulin sensitivity.

Abstract excerpt

A common polymorphism of the 54th codon of fatty acid-binding protein 2 (FABP2), in which threonine substitutes for alanine (T54), has been linked to insulin resistance and/or increased postprandial triglycerides in various studies. I propose that, in subjects expressing T54, the secretion of gastric inhibitory polypeptide (GIP) evoked by fatty meals is subnormal, such that adipocytes are less efficient in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alanine
• Share to Dietary Fats
• Share to Fatty Acid-Binding Protein 7