Article
Frequencies of variants of candidate genes in different age groups of hypertensives.
Clinical and experimental pharmacology & physiology - 1 Nov 1994
Zee R Y, Bennett C L, Schrader A P, Morris B J
Abstract excerpt
1. In severe, familial hypertension, we have reported that the proportion of patients homozygous for the deletion allele of an insertion/deletion polymorphism of the angiotensin I-converting enzyme gene is markedly decreased in older age groups, suggesting that this genotype is associated with increased risk of premature death. The aim of the present study was to examine the relationship with age, of variants of...
Topics
- Age Factors
- Alleles
- Carboxypeptidases
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Hypertension
- Middle Aged
- Polymorphism, Restriction Fragment Length