Article
Rapid prenatal diagnosis of aneuploidy from uncultured amniotic fluid cells using five-colour fluorescence in situ hybridization.
Prenatal diagnosis - 1 Nov 1994
Divane A, Carter N P, Spathas D H, Ferguson-Smith M A
Abstract excerpt
In this paper we describe the use of five-colour fluorescence in situ hybridization for prenatal diagnosis of aneuploidy using uncultured amniotic fluid cells. The analysis is based on ratio mixing of dual-labelled probes and digital imaging for the detection and visualization of five different p...
Topics
- Amniotic Fluid
- Aneuploidy
- Cells, Cultured
- Chromosome Aberrations
- Chromosome Disorders
- Female
- Genotype
- Humans
- In Situ Hybridization, Fluorescence
- Male
- Polymerase Chain Reaction
- Pregnancy
- Prenatal Diagnosis
- Retrospective Studies
- Sex Determination Analysis