Article
Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.
The Journal of biological chemistry - 3 Mar 1995
Kelly R J, Rouquier S, Giorgi D, Lennon G G, Lowe J B
Abstract excerpt
Synthesis of soluble A, B, H, and Lewis b blood group antigens in humans is determined by the Secretor (Se) (FUT2) blood group locus. Genetic, biochemical, and molecular analyses indicate that this locus corresponds to an alpha(1,2)fucosyltransferase gene distinct from the genetically-linked H bl...
Topics
- Alleles
- Base Sequence
- Blood Group Antigens
- Cloning, Molecular
- DNA
- DNA Primers
- Fucosyltransferases
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Phenotype
- Sequence Homology, Amino Acid