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Article

Genomic rearrangements in childhood spinal muscular atrophy: linkage disequilibrium with a null allele.

Journal of medical genetics - 1 Feb 1995

Daniels R J, Campbell L, Rodrigues N R, Francis M J, Morrison K E, McLean M, MacKenzie A, Ignatius J, Dubowitz V, Davies K E

Abstract excerpt

Autosomal recessive childhood onset spinal muscular atrophy has been mapped to chromosome 5q13. We report the analysis of a polymorphic microsatellite which shows linkage disequilibrium with the disease. The linkage disequilibrium is observed with a null allele which is seen as the non-inheritance of alleles from one or both parents. The inheritance of a null allele was observed in 26 out of 36 (72%) informative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7760328
DOI: 10.1136/jmg.32.2.93
PMCID: PMC1050226

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