Genomic imprinting--defusing the ovarian time bomb.

doi:10.1016/0168-9525(94)90212-7

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Article

Genomic imprinting--defusing the ovarian time bomb.

Trends in genetics : TIG - 1 Apr 1994

Varmuza S, Mann M

Abstract excerpt

Why do mammals imprint their parental genomes? Imprinting is seen in many phyla, but that in mammals is by far the most dramatic. Is there something peculiar to mammals that calls for such a striking phenomenon? We propose that imprinting is a device that protects female mammals from the potential ravages of ovarian trophoblast disease. Without imprinting, the ovarian teratomas that frequently arise from...

Topics

Alleles
Animals
Choriocarcinoma
Embryonic and Fetal Development
Female
Gene Expression Regulation
Humans
Male
Mammals
Methylation
Mice
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oocytes

Ovarian Neoplasms

Parents

Parthenogenesis

Phenotype

Pregnancy

Source

Open in PubMed

Identifiers

PMID: 7848407
DOI: 10.1016/0168-9525(94)90212-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7848407-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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