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Maternal–fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer

10 Jun 2015

Abstract excerpt

Antagonistic coevolution between maternal and fetal genes, and between maternally and paternally derived genes may have increased mammalian vulnerability to cancer. Placental trophoblast has evolved to invade maternal tissues and evade structural and immunological constraints on its invasion. These adaptations can be co-opted by cancer in intrasomatic selection. Imprinted genes of maternal and paternal origin...

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PMID: 26056362
DOI: 10.1098/rstb.2014.0178

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