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Article

Use of the polymerase chain reaction in the detection of AML1/ETO fusion transcript in t(8;21)

1 Feb 1995

Abstract excerpt

BACKGROUND: t(8;21)(q22;q22), found in acute myeloid leukemia (AML) and occasionally in myelodysplasia (MDS), results in the fusion of the AML1 gene on 22q22 to the ETO gene on 8q22, generating a chimeric AML1/ETO transcript, which is a molecular marker of the translocation. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR), with two pairs of nested AML1 and ETO primers, was used to amplify the...

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PMID: 7828132
DOI: 10.1002/1097-0142(19950201)75:3<821::aid-cncr2820750312>3.0.co;2-z

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