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Article

Genetic heterogeneity of autosomal recessive limb-girdle muscular dystrophy in a genetic isolate (Amish) and evidence for a new locus.

Human molecular genetics - 1 Mar 1995

Allamand V, Broux O, Bourg N, Richard I, Tischfield J A, Hodes M E, Conneally P M, Fardeau M, Jackson C E, Beckmann J S

Abstract excerpt

Limb-girdle muscular dystrophy (LGMD) is a hereditary myopathy presenting clinical and genetic heterogeneity. In 1991, a recessive form (LGMD2A) was linked to chromosome 15q in a genetic isolate from the Isle of La Réunion. Confirmation of this localization was subsequently reported in Brazilian and northern Indiana Amish pedigrees. Here we report the exclusion of the LGMD2A locus in six Amish kindreds from...

Topics

Chromosomes, Human, Pair 15
Genetic Heterogeneity
Genetic Linkage
Genetic Markers
Genotype
Humans
Indiana
Muscular Dystrophies
Pedigree
White People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7795603
DOI: 10.1093/hmg/4.3.459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7795603-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic heterogeneity of autosomal recessive limb-girdle muscular dystrophy in a genetic isolate (Amish) and evidence for a new locus.PMID 7795603Read ↗

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