Article
A 3-deazauracil-resistant mutant of Bacillus subtilis with increased production of cytidine.
Bioscience, biotechnology, and biochemistry - 1 May 1995
Asahi S, Tsunemi Y, Izawa M, Doi M
Abstract excerpt
Bacillus subtilis No. 344 is a cytidine-producing mutant strain derived from wild type strain No. 122. When 3-deazauracil-resistant mutants were derived from strain No. 344, some of the mutants had higher productivities of cytidine. Among them, strain No. 428 accumulated 14.2 mg/ml cytidine in the culture. Cytidine 5'-triphosphate (CTP) synthetase from strain No. 428 changed to be free from feedback inhibition by...
Topics
- Bacillus subtilis
- Carbon-Nitrogen Ligases
- Cell Division
- Cytidine
- Drug Resistance, Microbial
- Ligases
- Mutation
- Pyridones
- Pyrimidines
- Uracil