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Article

Efficient production of menaquinone (vitamin K2) by a menadione-resistant mutant of Bacillus subtilis.

Journal of industrial microbiology & biotechnology - 1 Mar 2001

Sato T, Yamada Y, Ohtani Y, Mitsui N, Murasawa H, Araki S

Abstract excerpt

Efficient production of menaquinone (MK) by Bacillus subtilis was achieved. An edible strain of B. subtilis, isolated from the traditional Japanese food natto, was mutated to improve MK productivity. A menadione-resistant mutant producing 30% more MK than its parent strain was obtained. Soybean extract and glycerol were the best nitrogen and carbon sources, respectively, among the sources tested. Addition of...

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Identifiers

PMID: 11420649
DOI: 10.1038/sj.jim.7000089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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