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Article

Extent of shock-induced membrane leakage in human and mouse myotubes depends on dystrophin

1 Feb 1995

Abstract excerpt

A lack of the cytoskeletal protein dystrophin causes muscle fiber necrosis in Duchenne/Becker muscular dystrophies (DMD/BMD) and in murine X-linked muscular dystrophy (MDX). However, no overt disease symptoms are observed in dystrophin-less cultured myotubes, and the biological function of dystrophin in normal muscle cells is still unknown. In this work, we have extended our studies on a model system, using...

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Identifiers

PMID: 7769014
DOI: 10.1242/jcs.108.2.727

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