Mutations in the complementarity-determining regions do not cause differences in free energy during the process of formation of the activated complex between an antibody and the corresponding protein antigen.

doi:10.1006/jmbi.1995.0255

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Article

Mutations in the complementarity-determining regions do not cause differences in free energy during the process of formation of the activated complex between an antibody and the corresponding protein antigen.

Journal of molecular biology - 12 May 1995

Ito W, Yasui H, Kurosawa Y

Abstract excerpt

Effects of mutations on antigen-antibody interactions were energetically examined using several kinds of Fv fragments, derivatives of a monoclonal antibody, D1.3, that is specific for hen egg-white lysozyme. According to the transition-state theory, the thermodynamic parameters involved in pre an...

Topics

Animals
Antigen-Antibody Reactions
Chickens
Immunoglobulin Fragments
Kinetics
Muramidase
Mutation
Thermodynamics

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