Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum.

doi:10.1089/dna.1995.14.373

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum.

DNA and cell biology - 1 May 1995

Ramakrishnan M, Tugizov S, Pereira L, Lee A S

Abstract excerpt

GRP94 is a major glycoprotein in the endoplasmic reticulum with calcium-binding properties. Recently, GRP94 has been shown to bind to unassembled forms of multimeric proteins and peptides. We report here that GRP94 forms a stable association with the mutated form of the herpes simplex type virus 1 (HSV-1) glycoprotein B, but not with the fully processed viral protein. Both the glycosylated and unglycosylated...

Topics

Animals
Base Sequence
Cell Line
Cricetinae
Cricetulus
Endoplasmic Reticulum
Gene Expression Regulation
HSP70 Heat-Shock Proteins
Membrane Proteins
Molecular Chaperones
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

Promoter Regions, Genetic

Regulatory Sequences, Nucleic Acid

Transfection

Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 7748487
DOI: 10.1089/dna.1995.14.373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7748487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum.PMID 7748487Read ↗

Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.Semantic proximity Read ↗

The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complexSemantic proximity Read ↗

The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.Semantic proximity Read ↗

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.Semantic proximity Read ↗

RREB-1 Is a Transcriptional Repressor of HLA-GSemantic proximity Read ↗

Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90.Semantic proximity Read ↗

Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contextsSemantic proximity Read ↗

Intimate Relationship Between Stress and Human Alpha-Herpes Virus 1 (HSV-1) Reactivation from LatencySemantic proximity Read ↗

Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.Semantic proximity Read ↗

Endoplasmic Reticulum Stress Induction of the Grp78/BiP Promoter: Activating Mechanisms Mediated by YY1 and Its Interactive Chromatin ModifiersSemantic proximity Read ↗

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5pSemantic proximity Read ↗

Characterisation of the isoforms of GRP78 using two-dimensional electrophoresis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.