Article
Giardia lamblia trophozoites contain multiple alleles of a variant-specific surface protein gene with 105-base pair tandem repeats.
Molecular and biochemical parasitology - 1 Dec 1994
Yang Y M, Ortega Y, Sterling C, Adam R D
Abstract excerpt
Giardia lamblia trophozoites undergo antigenic variation of a variant-specific surface protein (VSP). All VSPs that have been reported have had high cysteine contents, including numerous copies of a CXXC motif. The first vsp gene described (vspA6; from the cloned line, WBA6), contained 21 copies of a 195 base pair tandem repeat, but other reported VSPs have not contained repeats. In this report, we describe the...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Antigens, Protozoan
- Antigens, Surface
- Base Sequence
- Cloning, Molecular
- DNA, Protozoan
- Electrophoresis, Gel, Pulsed-Field
- Genes, Protozoan