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Article

Phenotypic expression and frequency of familial defective apolipoprotein B-100 in Belgian hypercholesterolemics.

Atherosclerosis - 1 Dec 1994

Kotze M J, Peeters A V, Langenhoven E, Wauters J G, Van Gaal L F

Abstract excerpt

DNA screening for apolipoprotein (apo) B mutations causing familial defective apolipoprotein B-100 (FDB) was performed in 87 hyperlipidemic Belgian individuals using heteroduplex analysis. Eighteen FDB heterozygotes from 5 unrelated families were identified. Three of the index cases reported an early family history of premature coronary heart disease (CHD). The frequency of the apo B3500 mutation was 8% in...

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PMID: 7718024
DOI: 10.1016/0021-9150(94)90096-5

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