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CJ-12,371 and CJ-12,372, Two Novel DNA Gyrase Inhibitors. Fermentation, Isolation, Structural Elucidation and Biological Activities.

1 Jan 1995

Abstract excerpt

A fermentation broth of an unidentified fungus (N983-46) was found to produce DNA gyrase inhibitors, CJ-12,371 (1) and CJ-12,372 (2). Following isolation by solvent extraction and silica gel and ODS (reverse phase) chromatographies, the structures were determined to be novel spiro-ketal compounds with S-configuration at position C-1. CJ-12,371 and CJ-12,372 inhibit both DNA supercoiling and relaxation mediated by...

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PMID: 7706123
DOI: 10.7164/antibiotics.48.134

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