Article
The significance of DNA double-strand breaks in the UV inactivation of yeast cells.
Mutation research - 1 May 1993
Kiefer J, Feige M
Abstract excerpt
The radiation-sensitive mutant rad 54-3 of Saccharomyces cerevisiae temperature-conditional for the repair of DNA double-strand breaks was exposed to 254 nm ultraviolet radiation and incubated at the restrictive and permissive temperatures. A large difference in survival was seen indicating the involvement of double-strand breaks in cellular inactivation at least in this strain. Pulsed-field gel electrophoresis...
Topics
- DNA Damage
- DNA, Fungal
- Dose-Response Relationship, Radiation
- Mutation
- Saccharomyces cerevisiae
- Temperature
- Ultraviolet Rays