Article
Mouse 3T3 fibroblasts induce rat basophilic leukemia (RBL-2H3) cells to acquire responsiveness to compound 48/80.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1993
Swieter M, Midura R J, Nishikata H, Oliver C, Berenstein E H, Mergenhagen S E, Hascall V C, Siraganian R P
Abstract excerpt
2H3 subline of rat basophilic leukemia (RBL-2H3) cells are mast cell analogs that lack responsiveness to nonimmunologic stimuli such as compound 48/80 and substance P. To determine if fibroblasts can influence this responsiveness, RBL-2H3 cells were cocultured with confluent monolayers of mouse 3T3 fibroblasts and assayed for secretagogue-induced histamine release. After 1 wk in coculture, RBL-2H3 cells began to...
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