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Article

Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Chen L, Keramati L, Helmann J D

Abstract excerpt

The Bacillus subtilis mrgA gene encodes an abundant DNA-binding protein that protects cells against the lethal effects of H2O2. Transcription of mrgA is induced by H2O2 or by entry into stationary phase when manganese and iron levels are low. We have selected for strains derepressed for transcription of mrgA in the presence of Mn(II). The resulting cis-acting mutants define an operator site just upstream of the...

Topics

Bacillus subtilis
Bacterial Proteins
Base Sequence
Catalase
Cations, Divalent
DNA-Binding Proteins
Gene Expression Regulation, Bacterial
Genes, Bacterial
Heme
Hydrogen Peroxide
Manganese

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Operator Regions, Genetic

Oxidative Stress

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7667267
DOI: 10.1073/pnas.92.18.8190
PMCID: PMC41122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7667267-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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