Article
[Familial amyloidotic polyneuropathy (FAP type I) with late-onset; siblings showing heterogeneity in age of onset].
Rinsho shinkeigaku = Clinical neurology - 1 May 1995
Umemura T, Sobue G, Morishita S, Tanaka F, Doyu M, Sakakibara T
Abstract excerpt
A 66-year-old man with late-onset FAP type I with Val30-->Met mutation in transthyretin was described. The age of clinical onset was 62 years old. The somatic motor and sensory involvement predominantly distributing in the distal part of the extremities preceded the manifestation of autonomic symptoms. He was diagnosed as having somatic motor and sensory neuropathy. However, 4 years after the onset, autonomic...
Topics
- Age of Onset
- Aged
- Amyloid Neuropathies
- Family Health
- Humans
- Male
- Mutation
- Pedigree
- Prealbumin