Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction.

doi:10.1172/JCI118207

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Article

Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction.

The Journal of clinical investigation - 1 Sept 1995

Fumeron F, Betoulle D, Luc G, Behague I, Ricard S, Poirier O, Jemaa R, Evans A, Arveiler D, Marques-Vidal P

Abstract excerpt

A polymorphism of the CETP gene (CETP/TaqIB) with two alleles B1 (60%) and B2 (40%) has been investigated in relation to lipid variables and the risk of myocardial infarction in a large case-control study (ECTIM) of men aged 25-64. No association was observed between the polymorphism and LDL or VLDL related lipid variables. Conversely, B2 carriers had reduced levels of plasma CETP (P < 0.0001) and increased...

Topics

Adult
Alcohol Drinking
Alleles
Analysis of Variance
Base Sequence
Carrier Proteins
Case-Control Studies
Cholesterol Ester Transfer Proteins
Cholesterol Esters
Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Introns

Lipoproteins, HDL

Lipoproteins, LDL

Lipoproteins, VLDL

Male

Middle Aged

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 7657837
DOI: 10.1172/JCI118207
PMCID: PMC185794

Genes

CETP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7657837-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Alcohol intake modulates the effect of a polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardial infarction.PMID 7657837Read ↗

Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and womenSemantic proximity Read ↗

The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample.Semantic proximity Read ↗

CETP TaqIB genotype modifies the association between alcohol and coronary heart disease: the INTERGENE case-control study.Semantic proximity Read ↗

Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study.Semantic proximity Read ↗

Extensive association analysis between the CETP gene and coronary heart disease phenotypes reveals several putative functional polymorphisms and gene-environment interaction.Semantic proximity Read ↗

Common cholesteryl ester transfer protein gene variation related to high-density lipoprotein cholesterol is not associated with decreased coronary heart disease risk after a 10-year follow-up in a Mediterranean cohort: Modulation by alcohol consumption.Semantic proximity Read ↗

Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis.Semantic proximity Read ↗

A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men.Semantic proximity Read ↗

An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.Semantic proximity Read ↗

CETP gene variation: relation to lipid parameters and cardiovascular risk.Semantic proximity Read ↗

Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population.Semantic proximity Read ↗

CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction.Semantic proximity Read ↗

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