Synthesis and in Vitro and in Vivo Antitumor Activity of a Series of Trans Platinum Antitumor Complexes

Abstract excerpt

The synthesis of a series of platinum complexes of trans coordination geometry [centered around the general formula, trans-ammine(amine)dichlorodihydroxoplatinum(IV) plus corresponding tetrachloroplatinum(IV) or Pt(II) counterparts] is described as part of a drug discovery program to identify more effective platinum-based anticancer drugs, particularly targeted toward the circumvention of resistance to cisplatin....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Click Chemistry and Applications
• Share to Metal complexes synthesis and properties
• Share to Nanoparticle-Based Drug Delivery