Article
A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency.
Cell - 28 Jul 1995
Schmidt B, Selmer T, Ingendoh A, von Figura K
Abstract excerpt
Multiple sulfatase deficiency (MSD) is a lysosomal storage disorder characterized by a decreased activity of all known sulfatases. The deficiency of sulfatases was proposed to result from the lack of a co- or posttranslational modification that is common to all sulfatases and required for their c...
Topics
- Alanine
- Aldehydes
- Amino Acid Sequence
- Animals
- Cell Line
- Conserved Sequence
- Cysteine
- DNA, Complementary
- Fibroblasts
- Humans
- Lysosomal Storage Diseases
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Sulfatases