Molecular basis for chemoprevention of colorectal carcinogenesis.

Abstract excerpt

Colorectal cancer is a common disease that frequently produces limited survival in afflicted patients. Recently a genetic model for tumorigenesis has been defined and has led to a better understanding of the interrelationships between environmental mutagens and genes. Epidemiologic studies have identified multiple chemopreventive agents that appear to reduce the risk of developing colorectal cancer. Their...

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