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Article

Overexpression of arylsulfatase A gene in fibroblasts from metachromatic leukodystrophy patients does not induce a new phenotype.

Gene therapy - 1 Aug 1995

Ohashi T, Matalon R, Barranger J A, Eto Y

Abstract excerpt

We tested the influence of overexpression of arylsulfatase A (ASA) on the activity of other sulfatases in fibroblasts from patients with metachromatic leukodystrophy (MLD). We demonstrated that the overexpression of ASA reduces the activity of various sulfatases by a small amount but does not induce an accumulation of glycosaminoglycan. Our results indicate that influence of ASA overexpression on other sulfatases...

Topics

Cells, Cultured
Cerebroside-Sulfatase
Fibroblasts
Gene Expression
Genetic Vectors
Glycosaminoglycans
Humans
Leukodystrophy, Metachromatic
Lysosomes
Phenotype
Retroviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Subcellular Fractions

Sulfatases

Transfection

Source

Identifiers

PMID: 7584110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7584110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Overexpression of arylsulfatase A gene in fibroblasts from metachromatic leukodystrophy patients does not induce a new phenotype.PMID 7584110Read ↗

Identification of a mutation in the arylsulfatase A gene of a patient with adult-type metachromatic leukodystrophy.Semantic proximity Read ↗

Safety of Arylsulfatase A Overexpression for Gene Therapy of Metachromatic LeukodystrophySemantic proximity Read ↗

Genotype-phenotype relationship in various degrees of arylsulfatase A deficiency.Semantic proximity Read ↗

The R496H mutation of arylsulfatase A does not cause metachromatic leukodystrophy.Semantic proximity Read ↗

Metachromatic leukodystrophy: Molecular genetics and an animal modelSemantic proximity Read ↗

Somatic intragenic recombination of the arylsulfatase A gene in a metachromatic leukodystrophy patient.Semantic proximity Read ↗

Mutations in the arylsulfatase A gene of Japanese patients with metachromatic leukodystrophy.Semantic proximity Read ↗

Bone marrow stem cell gene therapy of arylsulfatase A-deficient mice, using an arylsulfatase A mutant that is hypersecreted from retrovirally transduced donor-type cells.Semantic proximity Read ↗

A new polymorphism of arylsulfatase A within the coding region.Semantic proximity Read ↗

Characterization of four arylsulfatase A missense mutations G86D, Y201C, D255H, and E312D causing metachromatic leukodystrophy.Semantic proximity Read ↗

[Molecular analysis of Japanese patients with metachromatic leukodystrophy].Semantic proximity Read ↗

Prevalence of common mutations in the arylsulphatase A gene in metachromatic leukodystrophy patients diagnosed in Britain.Semantic proximity Read ↗

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