Article
Marked detergents effects on safranine T-mediated photo-induced electron transfer in cytochrome P-450 1A2.
Biochimica et biophysica acta - 25 Oct 1995
Nakano R, Konami H, Sato H, Ito O, Shimizu T
Abstract excerpt
Cytochrome P-450 accepts electrons from electron transfer proteins to facilitate monooxidation reactions. It is suggested that basic amino acids such as Lys and Arg on the P-450 molecular surface interact with acidic amino acids such as Glu and Asp of the electron transfer protein. Safranine T is a basic compound which mediates electron transfer with illumination. It was found with flash photolysis that an...
Topics
- Animals
- Cholic Acid
- Cholic Acids
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Detergents
- Kinetics
- Liver
- Mutation
- Nonoxynol
- Oxidation-Reduction
- Oxidoreductases