Overexpression of DM20 messenger RNA in two brothers with Pelizaeus-Merzbacher disease.

doi:10.1002/ana.410380409

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Article

Overexpression of DM20 messenger RNA in two brothers with Pelizaeus-Merzbacher disease.

Annals of neurology - 1 Oct 1995

Carango P, Funanage V L, Quirós R E, Debruyn C S, Marks H G

Abstract excerpt

Pelizaeus-Merzbacher disease is a rare, sex-linked recessive, dysmyelinating disease of the central nervous system that has been associated with mutations in the myelin proteolipid protein (PLP) gene. Only 25% of patients studied with Pelizaeus-Merzbacher disease have exonic mutations in this gene, the underlying cause of the disease in the remaining patients is unknown. The PLP gene encodes two major...

Topics

Adolescent
Adult
Base Sequence
Cells, Cultured
Child
Child, Preschool
Diffuse Cerebral Sclerosis of Schilder
Female
Fibroblasts
Gene Expression
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Myelin Proteins

Myelin Proteolipid Protein

RNA Splicing

Source

Open in PubMed

Identifiers

PMID: 7574457
DOI: 10.1002/ana.410380409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7574457-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Overexpression of DM20 messenger RNA in two brothers with Pelizaeus-Merzbacher disease.PMID 7574457Read ↗

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