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Article

Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995

Phillips J P, Tainer J A, Getzoff E D, Boulianne G L, Kirby K, Hilliker A J

Abstract excerpt

Mutations in Cu/Zn superoxide dismutase (SOD), a hallmark of familial amyotrophic lateral sclerosis (FALS) in humans, are shown here to confer striking neuropathology in Drosophila. Heterozygotes with one wild-type and one deleted SOD allele retain the expected 50% of normal activity for this dimeric enzyme. However, heterozygotes with one wild-type and one missense SOD allele show lesser SOD activities, ranging...

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Identifiers

PMID: 7567977
DOI: 10.1073/pnas.92.19.8574
PMCID: PMC41008

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