Article
Functional characterization of an inositol-sensitive upstream activation sequence in yeast. A cis-regulatory element responsible for inositol-choline mediated regulation of phospholipid biosynthesis.
The Journal of biological chemistry - 20 Oct 1995
Bachhawat N, Ouyang Q, Henry S A
Abstract excerpt
A repeated element, the inositol-sensitive upstream activation sequence (UASINO), having the consensus sequence, 5'-CATGTGAAAT-3', is present in the promoters of genes encoding enzymes of phospholipid biosynthesis that are regulated in response to the phospholipid precursors, inositol and choline. None of the naturally occurring variants of the UASINO element exactly recapitulates the consensus (for review, see...
Topics
- Base Sequence
- Binding Sites
- Choline
- Genes, Regulator
- Helix-Loop-Helix Motifs
- Inositol
- Molecular Sequence Data
- Mutation
- Phospholipids
- Promoter Regions, Genetic