Article
A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10.
Endocrine journal - 1 Apr 1995
Suzuki Y, Kadowaki H, Atsumi Y, Hosokawa K, Katagiri H, Kadowaki T, Oka Y, Uyama K, Mokubo A, Asahina T
Abstract excerpt
We report the case of 71-year-old male who was once diagnosed as having diabetic amyotrophy, because of pronounced wasting in proximal muscles, massive weight loss, and development of paresthesia in his legs. Afterwards, ragged red fibers and mitochondrial tRNA mutation at position 3243 were documented in muscle biopsy. He had diabetes mellitus associated with 3243 mitochondrial DNA mutation, suggesting that...
Topics
- Animals
- Coenzymes
- Diabetes Complications
- Diabetes Mellitus
- Humans
- Male
- Muscular Diseases
- Mutation
- RNA
- RNA, Mitochondrial
- RNA, Transfer, Leu