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Article

Heat shock protein HSP60 can alleviate the phenotype of mitochondrial RNA-deficient temperature-sensitive mna2 pet mutants.

Molecular & general genetics : MGG - 6 Jan 1995

Sanyal A, Harington A, Herbert C J, Groudinsky O, Slonimski P P, Tung B, Getz G S

Abstract excerpt

mna2, which belongs to the class I temperature-sensitive pet mutants that lose mitochondrial (mt)RNA at restrictive temperature, was shown by complementation and sequence determination to correspond to the gene coding for HSP60. Both mna2-1 and mna2-2, the two available alleles of mna2, have conservative single amino acid substitutions in the HSP60 gene. Valine substitutes for an alanine (position 47) in mna2-1,...

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PMID: 7529869
DOI: 10.1007/BF00290133

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