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Article

Relationship between the V3 loop and the phenotypes of human immunodeficiency virus type 1 (HIV-1) isolates from children perinatally infected with HIV-1.

Journal of virology - 1 Jan 1995

Mammano F, Salvatori F, Ometto L, Panozzo M, Chieco-Bianchi L, De Rossi A

Abstract excerpt

The third variable region (V3) of the envelope protein of human immunodeficiency virus type 1 (HIV-1) contains group- and type-specific epitopes for neutralizing antibodies and contains determinants involved in viral tropism and syncytium-inducing (SI) activity. We studied the in vivo relationship between V3 sequences and viral phenotypes in 24 perinatally HIV-1-infected children. To avoid in vitro selection of...

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Identifiers

PMID: 7527089
DOI: 10.1128/JVI.69.1.82-92.1995
PMCID: PMC188551

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