Article
Cystic fibrosis in a low-incidence population: two major mutations in Finland.
Human genetics - 1 Feb 1994
Kere J, Estivill X, Chillón M, Morral N, Nunes V, Norio R, Savilahti E, de la Chapelle A
Abstract excerpt
The incidence of cystic fibrosis (CF) in Finland, 1:25,000 newborn, is one of the lowest in Caucasian populations. The delta F508 mutation accounts for 18/40 (45%) of CF chromosomes in Finland. Other mutations were therefore sought among the remaining 55%. Twelve out of 40 chromosomes (30%) were...
Topics
- Adult
- Base Sequence
- Child, Preschool
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA Mutational Analysis
- Electrophoresis, Polyacrylamide Gel
- Female
- Finland
- Haplotypes
- Humans
- Incidence