Article
A new type of G-->A hypermutation affecting human immunodeficiency virus.
AIDS research and human retroviruses - 1 Sept 1993
Fitzgibbon J E, Mazar S, Dubin D T
Abstract excerpt
A form of G-->A hypermutation preferentially affecting GA dinucleotides of genomic RNA has been found to occur in retroviral systems ("type 1"). In a detailed longitudinal study of an AIDS patient we have observed a new type of G-->A hypermutation, which preferentially affects one or more 5' G re...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Consensus Sequence
- DNA Mutational Analysis
- DNA, Viral
- Follow-Up Studies
- Genes, pol
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Proviruses
- RNA-Directed DNA Polymerase
- Sequence Alignment
- Sequence Homology