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Article

New phenotype of the cerebral autosomal dominant arteriopathy mapped to chromosome 19: migraine as the prominent clinical feature.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 1995

Vérin M, Rolland Y, Landgraf F, Chabriat H, Bompais B, Michel A, Vahedi K, Martinet J P, Tournier-Lasserve E, Lemaitre M H

Abstract excerpt

A survey was carried out on a large family presenting the symptoms of familial arteriopathy (CADASIL) recently mapped to chromosome 19. This is characterised clinically by recurrent subcortical infarcts developing into pseudobulbar palsy and subcortical dementia, and radiologically by early MRI abnormalities. To characterise this familial condition, 43 members older than 20 years and spreading over four...

Topics

Adult
Aged
Cerebral Infarction
Chromosome Aberrations
Chromosome Disorders
Chromosome Mapping
Chromosomes, Human, Pair 19
Diffuse Cerebral Sclerosis of Schilder
Female
Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Magnetic Resonance Imaging

Male

Mental Disorders

Middle Aged

Migraine Disorders

Pedigree

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7500094
DOI: 10.1136/jnnp.59.6.579
PMCID: PMC1073751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7500094-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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