Article
Anti-HBV neonatal immunization with recombinant vaccine. Part II. Molecular basis of the impaired alloreactivity.
Vaccine - 1 Apr 1995
Martinetti M, Cuccia M, Daielli C, Ambroselli F, Gatti C, Pizzochero C, Belloni C, Orsolini P, Salvaneschi L
Abstract excerpt
HLA study was performed in 9 absolute non-responder (serum titre of anti-HBsAg < 2 mIU ml-1) and 8 hyporesponder (serum antibody level between 2 and 9.9 mIU ml-1) babies who underwent, in neonatal period, HBV vaccination with Engerix B recombinant vaccine. The investigation pointed out that many of these subjects carry HLA haplotypes classically involved in autoimmune diseases: namely HLADR7; DQ2, DR4; DQ8 and...
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