Article
Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma.
Nature - 1 Jan 2000
Godbout R, Dryja T P, Squire J, Gallie B L, Phillips R A
Abstract excerpt
Through family studies and analysis of patients with congenital chromosome abnormalities, the germ-line mutation responsible for the hereditary form of the eye tumour, retinoblastoma, has been assigned to the q14 region on chromosome 13 and closely linked to an enzyme called esterase D (ESD). Knudson has proposed that as few as one somatic event in addition to the germ-line mutation is required to induce tumours...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.