Article
Quantification of the close association between DNA haplotypes and specific beta-thalassaemia mutations in Mediterraneans.
Nature - 1 Jan 2000
Kazazian H H, Orkin S H, Markham A F, Chapman C R, Youssoufian H, Waber P G
Abstract excerpt
It has been suggested that there is a close linkage between specific restriction fragment polymorphism patterns, defined as haplotypes, in the beta-globin gene cluster and specific mutations in Mediterranean people with thalassaemia. This association formed the basis of a strategy for the efficie...
Topics
- Alleles
- Base Sequence
- DNA
- Europe
- Gene Frequency
- Humans
- Mutation
- Nucleic Acid Hybridization
- Thalassemia