Article
Relationship of genotype and in vitro contractility in mdg/mdg in equilibrium +/+ "mosaic" myotubes.
Muscle & nerve - 1 Jan 2000
Peterson A, Pena S
Abstract excerpt
Muscular dysgenesis (mdg) in the mouse is an autosomal recessive lethal disorder that is manifested by a gross failure of skeletal muscle development. In vitro mdg/mdg myoblasts proliferate normally and fuse successfully into myotubes, but these myotubes fail to contract either spontaneously or in response to physiological stimuli despite the presence of effective contractile elements and an ability to propagate...
Topics
- Acetylcholine
- Animals
- Cells, Cultured
- Genes, Lethal
- Genotype
- Glucose-6-Phosphate Isomerase
- In Vitro Techniques
- Isoenzymes
- Mice
- Muscle Contraction
- Muscles
- Mutation