Article
[Selection of Streptomyces spheroides--a producer of extracellular proteases with fibrinolytic action].
Mikrobiologiia - 1 Jan 2000
Egorov N S, Al-Nuri M A, Prianishnikova N I
Abstract excerpt
The mutagenic action of UV on Streptomyces spheroides 35 spores produced mutants with an elevated biosynthesis of exocellular proteases having the fibrinolytic activity. During submerged cultivation, mutant M8-2 accumulated 4-5 times more fibrinolytic enzymes with a high thrombolytic activity in the cultural broth than the parent strain. The selection of mutants synthesizing proteases with a high fibrinolytic...
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