[Microbiological method of determining cyanocobalamin in tissues and finished drugs made from animal raw materials].

Article

[Microbiological method of determining cyanocobalamin in tissues and finished drugs made from animal raw materials].

Farmakologiia i toksikologiia - 1 Jan 2000

Krylov Iu F, Prokhorov B S

Abstract excerpt

An assay for cyanocobalamin with the use of the test microorganism E. coli, mutant ATCC 9637, is offered. The measurement of the content of cyanocobalamin in the blood serum and liver of intact rats after intraperitoneal drug injection demonstrated its content to reach a maximum 30 minutes after injection and to depend on the dose. When given in doses 100 and 400 micrograms/kg, the drug dose in the serum amounted...

Topics

Animals
Biological Assay
Biological Products
Dose-Response Relationship, Drug
Escherichia coli
Female
Liver
Male
Mutation
Rats
Time Factors
Vitamin B 12

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