[Induction of alphavirus ts-mutations by N-methyl-N-nitro-N-nitrosoguanidine added to the replicating virus].

Article

[Induction of alphavirus ts-mutations by N-methyl-N-nitro-N-nitrosoguanidine added to the replicating virus].

Voprosy virusologii - 1 Jan 2000

Shablinskaia L M, Tsilinskiĭ Ia Ia

Abstract excerpt

The possibility of producing ts mutants of Sindbis and eastern equine encephalomyelitis (EEE) virus by treatment of replicating virus with N-methyl-N-nitro-N-nitrosoguanidine was studied. N-methyl-N-nitro-N-nitrosoguanidine added in a concentration of 20 micrograms/ml to chick fibroblast cultures...

Topics

Alphavirus
Animals
Chick Embryo
Encephalitis Virus, Eastern Equine
Methylnitronitrosoguanidine
Mutation
Sindbis Virus
Virus Cultivation
Virus Replication

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