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Article

[Selection and mutant properties of Pichia guilliermondii yeasts with derepressed GTP cyclohydrolase, the enzyme of the 1st step in flavinogenesis].

Mikrobiologiia - 1 Jan 2000

Shavlovskiĭ G M, Sibirnyĭ A A, Fedorovich D V, Seniuta E Z

Abstract excerpt

A positive method is proposed for selecting Pichia guilliermondii mutants with derepressed GTP cyclohydrolase. Mutants with the incompletely blocked gene RIB2 were used as parent strains; these can grow in a medium without riboflavin (RF) only if the enzyme is derepressed as the result of iron deficiency in cells. Strains growing in a medium without RF at the optimal supply of cells with iron were selected as...

Topics

Aminohydrolases
Ascomycota
Flavins
GTP Cyclohydrolase
Gene Expression Regulation
Genes
Mutation
Nucleotidyltransferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pichia

Riboflavin Synthase

Selection, Genetic

Source

Identifiers

PMID: 6280023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6280023-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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