Article
[Inactivation and mutagenesis of lambda phage by O-methylhydroxylamine and O-delta-aminooxybutylhydroxylamine].
Molekuliarnaia biologiia - 1 Jan 2000
Petrenko V A, Gusev V A, Semenova L N
Abstract excerpt
The inactivation and the mutagenesis of lambda phage Cl 857 virR by O-methylhydroxylamine (OMHA) and O-delta-aminooxybuthylhydroxylamine (delta-HA) were studied. The inactivation of OMHA-treated phage was shown to be stronger in E. coli polA cells defective in DNA-polymerase I as compared to wild-type host E. coli W3350. In contrast delta-HA caused similar phage inactivation in these two strains. Wave-type...
Topics
- Bacteriophage lambda
- Escherichia coli
- Hydroxylamines
- Kinetics
- Mutation
- Structure-Activity Relationship
- Virus Replication