Arabidopsis epigenetic factor AS2 mitigates nucleolar stress and promotes flat leaf development by repressing a CDK inhibitor.

doi:10.1242/dev.205275

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Article

Arabidopsis epigenetic factor AS2 mitigates nucleolar stress and promotes flat leaf development by repressing a CDK inhibitor.

Development (Cambridge, England) - 15 Sept 2026

Nakagawa Ayami, Iwakawa Hidekazu, Takahashi Hiro, Vial-Pradel Simon, Takahashi Mari, Ohga Kazuomi, Ito Takuma, Tamai Motoki, Takada Eri, Keta Sumie, Ishibashi Nanako, Ando Sayuri, Ohbayashi Iwai, Ito Masaki, Yamazaki Mami, Sato Ayato, Umeda Masaaki, Cha Byung-Yoon, Woo Je-Tae, Sasabe Michiko, Sugiyama Munetaka, Kojima Shoko, Machida Yasunori, Machida Chiyoko

Abstract excerpt

The Arabidopsis thaliana leaf, which exhibits a symmetrically extended flat morphology, consists of two distinct cellular domains: adaxial and abaxial layers. The ASYMMETRIC LEAVES2 (AS2) gene is essential for specifying the adaxial domain, and its protein forms nucleolar structures, termed AS2 bodies, at ribosomal-DNA loci. Numerous nucleolus-related genes have been reported to be cooperatively involved in leaf...

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Topics

Arabidopsis
Plant Leaves
Cell Nucleolus
Arabidopsis Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Camptothecin

Gene Expression Regulation, Plant

Transcription Factors

Cyclin-Dependent Kinases

Cyclin-Dependent Kinase Inhibitor Proteins

Mutation

Stress, Physiological

Source

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Identifiers

PMID: 42757687
DOI: 10.1242/dev.205275
PMCID: PMC13680833

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Arabidopsis epigenetic factor AS2 mitigates nucleolar stress and promotes flat leaf development by repressing a CDK inhibitor.PMID 42757687Read ↗

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