A multinational genomic framework for predicting β-lactam resistance in Haemophilus influenzae.

doi:10.1093/jac/dkag307

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Article

A multinational genomic framework for predicting β-lactam resistance in Haemophilus influenzae.

The Journal of antimicrobial chemotherapy - 1 Sept 2026

Deghmane Ala-Eddine, Asmi Maria, Abel Sören, Bajanca-Lavado Paula, Claus Heike, D'Aeth Joshua, Garcia Ignacio, Kiedrowska Marlena, Lam Thien-Tri, Litt David, Martiny Delphine, Meilleur Courtney, Skoczyńska Anna, Tzanakaki Georgina, Xirogianni Athanasia, Taha Muhamed-Kheir

Abstract excerpt

BACKGROUND: Haemophilus influenzae resistance to β-lactams is mediated by β-lactamase and amino acid alterations in penicillin-binding protein 3 encoded by ftsI gene, which shows incomplete phenotype-genotype concordance. OBJECTIVES: To develop and evaluate a genomic classification framework to predict clinically relevant β-lactam resistance categories. METHODS: We analysed 5288 H. influenzae isolates collected...

Read the complete abstract on PubMed

Topics

Haemophilus influenzae
beta-Lactam Resistance
Humans
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Anti-Bacterial Agents

Europe

Canada

Haemophilus Infections

Genotype

Genomics

beta-Lactams

Penicillin-Binding Proteins

Alleles

Amoxicillin

Source

Open in PubMed

Identifiers

PMID: 42747902
DOI: 10.1093/jac/dkag307

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