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Article

Unique Genetic Clades and Frequent Zoonotic Transmission of Sporothrix brasiliensis with Reduced Itraconazole Susceptibility.

Mycopathologia - 15 Sept 2026

Trápaga Mariana Rodrigues, Spruijtenburg Bram, Hidalgo Jéssica Estefania Dávila, Jacomel Bruna, Madrid Isabel Martins, Pereira Daniela Isabel Brayer, Mattei Antonella Souza, Gomes Angelita Reis, de Faria Renata Osório, Silveira Flávio, Severo Cecília Bittencourt, Aquino Valério Rodrigues, Franz Ana Paula Giolo, de Ávila Botton Sonia, Zancopé-Oliveira Rosely Maria, Poester Vanice Rodrigues, de Groot Theun, Meijer Eelco F J, Xavier Melissa Orzechowski

Abstract excerpt

Sporothrix brasiliensis is driving a major zoonotic epidemic in Brazil, predominantly via cat-to-human transmission. In the late 1990s major outbreaks were reported in Rio de Janeiro (RJ) and Rio Grande do Sul (RS), the southernmost state. We characterized the antifungal susceptibility and genetic diversity of 450 S. brasiliensis isolates collected between 2009 and 2024 in RS to better understand treatment...

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Topics

Sporothrix
Sporotrichosis
Itraconazole

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Brazil

Humans

Antifungal Agents

Cats

Microbial Sensitivity Tests

Genetic Variation

Zoonoses

Genotype

Drug Resistance, Fungal

Cat Diseases

Phylogeny

Microsatellite Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 42742838
DOI: 10.1007/s11046-026-01101-5
PMCID: PMC13578069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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