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Article

Asymmetric Functional Divergence of alx4a and alx4b in Iridophore Differentiation and Cranial Development in Nile Tilapia.

Cells - 22 Aug 2026

Shi Hongsheng, Fang Fugui, Yao Jiawen, Ju Siyu, Li Minghui, Wang Deshou

Abstract excerpt

Neural crest cells give rise to the craniofacial skeleton and multiple pigment cell lineages, yet how duplicated developmental regulators partition their ancestral functions after teleost-specific whole-genome duplication remains unclear. Here, we employed CRISPR/Cas9 to generate alx4a and alx4b single and double mutants in Nile tilapia (Oreochromis niloticus). By integrating phenotype, skeleton, transcriptome,...

Read the complete abstract on PubMed

Topics

Animals
Skull
Cichlids
Cell Differentiation
Fish Proteins
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Phenotype

Chromatophores

Source

Open in PubMed Open full text

Identifiers

PMID: 42738806
DOI: 10.3390/cells15171512
PMCID: PMC13564871

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